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KMID : 1189120070040020160
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대한의학유전학회지
2007 Volume.4 No. 2 p.160 ~ p.166
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The association between polymorphisms of β -adrenoceptors and preeclampsia
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Lim Ji-Hyae
Kim Shin-Young
Park So-Yeon
Yang Jae-Hyug
Han Jung-Yeol
Hong Dal-Soo
Choi June-Seek
Choi Kyu-Hong
Ryu Hyun-Mee
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Abstract
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Purpose : The β-adrenoceptors are Pharmacologically Classified into β 1-, β 2- 3nd β 3-adrenoceptor. The gene of each subtype has polymorphisms related to their function (β 1-adrenoceptor: Ser49Gly, β 2- adrenoceptor: Gln27Glu, β3-adrenoceptor: Trp64Arg). The objectives of this study were to analyse the allelic and genotypic distribution of the representative polymorphism of β-adrenoceptors in preeclampsia and to investigate whether combined genotype of β-adrenoceptors may be associated with preeclampsia.
Methods : Blood samples were collected from a Korean population (159 preeclamptic pregnancies and 168 normotensive pregnancies). The β1-, β2- and β3-adrenoceptor genotypes was determined using polymerase chain reaction-restriction fragment length polymorphism.
Results : There were no differences in allelic and genotypic distribution of β 1- and β 2-adrenoceptor polymorphisms between the two groups. However, the Arg allele of β3-adrenoceptor polymorphism were more frequent in preecalmpsia than in controls (P<0.05, OR=1.57, 95% Cl=1.01-2.46). Moreover, prevalence of genotype carrying heterozygote of β3-adrenoceptor polymorphism was increased in preeclampsia compared wlth controls (P<0.05, OR 1.76, 95% Cl 1.06-2.92). When combination of the three polymorphisms were evaluated, pregnancies with the particular combined genotype that is consisted of heterozyg ote of β1-, β 3-adrenoceptor and wild homozygote of β 2-adrenoceptor (Ser/Gly, Gln/Gln, Trp/Arg), showed a significant increase in the risk of preeclampsia (P<0.05, OR=3.01, 95% Cl 1.12-8.08).
Conclusion : A particular combined genotype (Ser/Gly, Gln/Gln, Trp/Arg) Of - adrenoceptors was associated with the risk of preeclampsia.
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KEYWORD
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β-adrenoceptor Polymorphisms, Preeclampsia
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